Down Syndrome

and Dementia

Down Syndrome and Alzheimer's Disease

The association of Down syndrome and Alzheimer's disease has been noted for many years and Down syndrome is considered a major risk factor for the disease. Numerous organizations have produced briefs on this association and guides for caregivers and others interested in knowing more. A brief list of the national organizations and links to their sites is provided to the right.

Alzheimer's Association (US)

Centers for Disease Control

Down Syndrome Resource Foundation

National Down Syndrome Society

National Institute on Aging

Down Syndrome & Dementia Resources

The NTG has been involved in efforts to better advocate for supports to adults with Down syndrome and and their families and provide information on dementia assessment and supports. These are some publications and documents that may be of use.

Down Syndrome and Dementia: A Guide for Families

Caregiver resource guide

Down Syndrome

and Dementia

Down Syndrome and Alzheimer's Disease

Down Syndrome & Dementia Resources

Down Syndrome and Dementia: A Guide for Families

Dohsa‐hou for unexplained regression in Down syndrome in a 19‐year‐old man: A case report

Down syndrome regression disorder, a case series: Clinical characterization and therapeutic approaches

Assessment and diagnosis of Down syndrome regression disorder: International expert consensus

Alternative diagnoses in the work up of Down syndrome regression disorder

Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome.

The Link between Alzheimer’s Disease and Down Syndrome. A Historical Perspective

Acute regression in Down syndrome

Down syndrome in a new era for Alzheimer Disease

End-of-life and Down syndrome: A companion guidebook to aging and down syndrome: A health and well-being guidebook

Regression in Persons with Down Syndrome: Current Consensus Update for Families

Mental Wellness in Adults with Down Syndrome: A Guide to Emotional and Behavioral Strengths and Challenges (2nd Ed.)

Regression (Down Syndrome)

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer’s disease

Dementia in Mentally Disabled Hard to Identify

The National Task Group on Intellectual Disabilities and Dementia Practices consensus recommendations for the evaluation and management of dementia in adults with intellectual disabilities

Importance in Overall Health in Adults with Intellectual Disability and Dementia

CMS decision on Aduhelm: An Explainer by LuMind IDSC

COVID-19 and Down Syndrome Resources Guide

NTG's FAQ on aducanumab and Down syndrome

Down Syndrome & Dementia News